Bioinformatics

EDIT: See below for original, I realized this could be done cleanly with a decorator . The decorator wrapplication takes the number of the port to use when called as a standalone server. The EMiddle class is unnecessary, it's just used as middleware to update the environ to show it came via wsgi. If there's a cleaner way, let me know. #!/usr/bin/python import os class EMiddle(object): def __init__(self, app): self.app = app def __call__(self, env, start_response): env['hello'] = 'wsgi' return self.app(env, start_response) def wrapplication(port): def wrapper(wsgi_app): if 'TERM' in os.environ: print "serving on port: %i" % port os.environ['hello'] = 'standalone' from wsgiref.simple_server import make_server make_server('', port, wsgi_app).serve_forever() elif 'CGI' in os.environ.get('GATEWAY_INTERFACE',...

Normally, I don't write libraries, I figure smarter people than I should do such things, and I should just use them. But, I got tired enough of writing one-off scripts for genomic feature manipulation-- find the upstream, downstream neighbors and get the sequence -- and I saw enough of the pieces coming together that I decided to build it. I'd complained before about how rtree didn't support 1D indicies. Not only is this not a problem, it's beneficial. Genomic features should have strand information, so that's the 2nd dimension. Then rtree does containment queries, so it's simple to find only the features on a given strand. I realized this about the same time that the docstring for numpy's memmap went from 0 lines to about 100, and it was enhanced to take a filehandle , not just a filename. This means you can send in a start position and a shape to the numpy.memmap constuctor and it can create a numpy array of only that chunk. This means that it's pos...

Traditional genome browsers, look like this . In fact, I think that's the most popular genome-browser used--gbrowse. They display information in tracks, so any layer of annotation you just add on to the bottom of the image (after making the image taller). This doesnt work for genome-browser, the hack of openlayers to support only horizontal scrolling, because you if you have 2 adjacent tiles, if one has more features than the next, there's not guarantee that they'll be the same height, and no guarantee that a feature that's on both images will align correctly. I was just hacking around, trying to test some work I'd done and realized that you can have annotation layers with OpenLayers, just add another map, and tie them together! So that's 2 OpenLayers.Map() instances. What makes this easy is the new Map.panTo() methods in OpenLayers 2.6 (which is in release candidate 1). So, the top map registers for 'move' and 'zoomend' events with callbacks th...